Double Nanopores

We have recently developed a novel mechanical approach to control the DNA motion through solid-state nanopores. The key element of our approach is a system of two nanopores drilled in parallel through the same solid-state membrane. During the electrophoretically driven passage of a DNA molecule through one of the nanopores, the untranslocated part of the same molecule can enter the second nanopore, leading to mechanical entrapment of the molecule. Such purely mechanical stalling of the DNA translocation may provide a breakthrough for future application of nanopores in biomolecular sensing and sequencing.