Exploring life at the nanoscale
A year ago our #CDLab was unpacking boxes, and little equipment could be seen 🧐 Today, 2 quantum light sources, and 10 researchers are found working hard every day, as well as some nights! 🤓😎 Looking forward to read this update again in one year time 😉 @univienna @JCLoredoR https://t.co/1fGOJIg9Bg 
Can SMC proteins incorporate other DNA-bound proteins in extruded DNA loops? How do they deal with roadblocks? Read the story by postdoc Biswajit Pradhan from our #CDlab and our collaborators from the Jan-Michael Peters lab at IMP Vienna: https://t.co/zveKDE0DgX https://t.co/ybGA46PcUC 
Today we put out a preprint https://t.co/uJvpZLxXS1 where we resolve this question on how SMCs deal with obstacles bound to DNA –yielding quite some surprises! Great experiments by postdoc Biswajit Pradhan et al of our #CDlab, in collaboration with Jan-Michael Peters et al. 1/7 https://t.co/YScqfjlLbR 
And the holy grails of nanopore sensing goes to #CDlab! Congratulations Henry, Cees and Alek! https://t.co/S1GEO9Rw8h
Today we released a preprint https://t.co/pm7lPCpyZm where we take a step towards the next challenge:
building a nanopore single-molecule PROTEIN sequencer! 😳 Awesome experiments by postdoc Henry Brinkerhoff of our #CDlab, augmented with MD simulations of @aksimentievLab
1/x https://t.co/j25Rg7bW54 
Dit najaar komen er 4 nieuwe postdocs bij ons #CDlab, met heel internationale achtergrond (US, China, Estland, Italië). Er is nog ruimte voor meer nieuwe mensen, ook bv voor Nederlandse promovendi kandidaten – https://t.co/UxV0WyNBwc
New paper out today in @ACSSynBio: https://t.co/LAialMT1Bf Here, we report an optimized method for reconstituting biological systems in liposomes. Great team effort led by @KGanzinger and @gijsjekoenderi1, with contributions from @DanelonLab and our #CDlab. https://t.co/VCdxGMwqoL 
Latest preprint to which our #CDlab contributed: https://t.co/J2GpR5D4X6 https://t.co/f8jMfu26RP
Latest #CDlab paper in @acsnano: https://t.co/HkfryIyByQ Lead authors @AlessioFragasso & NicolaDeFranceschi show that we can make ultrawide (30nm) origami pores in liposomes that allow transmembrane transport of huge (250kDa) proteins. Great collaboration with @hendrik_dietz lab https://t.co/kysTRaBCpw 
Out NOW! Our latest paper in @acsnano #CDlab We make 30nm-wide DNA-origami pores that span the membrane of giant liposomes To do this we have a special trick… 😉 if you are curious, check it out: https://t.co/s5BihymSlg Cool project in collaboration with the #Dietz lab
‘Diagnosing point-of-care diagnostics for neglected tropical diseases’ Latest #CDlab paper online in @PLOSNTDs: https://t.co/UOSFtb2gOz Here, lead authors @mitashabharadw & MichelBengtson et al review point-of-care diagnostics for the many horrible neglected tropical diseases. https://t.co/eDd5jz6MzU 
Latest #CDlab paper published: https://t.co/7aL3ESxg3X Here, we review what is known about chromosome segregation in bacteria: How chromosomes mutually disentangle and move apart after they are replicated before cell division. Great write by Christos Gogou & Sandro Japaridze! https://t.co/LqXr6MVe83 
Latest paper out in @NatureMethods – an interesting overview of single-molecule protein sequencing technologies, written by a large group of scientists led by #JavierAlfaro @ChirlminJoo_Lab @MellerLab, to which our #CDlab also contributed. https://t.co/Rv4kO4GrAQ https://t.co/ZTm4TLA4Ii 
Latest #CDlab paper online in @NatureComms! https://t.co/4tqU2MmNj7 Here we show that the height of a microchamber dramatically affects in vitro Min patterns, which was key to finally understand how in vitro and in vivo patterns relate. Superb collaboration with @PhysOfLifeLMU! https://t.co/EHV2K9LVyL 
Latest @biorxivpreprint #CDlab online: https://t.co/9ZlTQZsWuc This shows the interplay of 2 major organizers of chromosomes:
DNA supercoiling & SMC-driven DNA loop extrusion Lots of surprises (extruding DNA loops absorb plectonemes!)
Read this cool paper by @eugene_kim__ et al https://t.co/adfahF3Kx7 
@sciSonja @WanunuLab @the_adam_hall @BehrendsLab ah, you mean beers at our #CDlab group trip to Ireland? I dont remember…
Latest paper #CDlab and @ChirlminJoo_Lab:
AutoStepfinder, a fast and automated step detection method for single-molecule analysis https://t.co/be8b1CqDJu Here @l_loeff & @jacobkers show a bias-free automated step-detection method Try it out on your data! https://t.co/70mciHyXtk https://t.co/bdN5oiPxGo 
Latest paper now in @NatureComms:
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in Bacillus subtilis cell division. https://t.co/U3ZS2zmVsE Great work by postdoc @KevinDWhitley in lab @seamus_holden, to which our #CDlab also contibuted https://t.co/rx0rfln1gu 
Latest #CDlab paper online: ‘DNA sequence-directed cooperation between nucleoid-associated proteins’. https://t.co/6umx5GSnrf In here, postdoc Aleksandre Japaridze shows that the sequential order of DNA-binding sites for proteins along DNA governs the higher-order architecture https://t.co/Cw9U9nDaH6 
Say hello 👋 to @Wayne_YangWW! 👇 Just transiting from #CDlab 🇳🇱 => 🇨🇭@LabRadenovic . #nanochannels #nanopores #2Dmaterials #optoelectronics he likes afaik 🙂 https://t.co/4SFJKNeywa
