Our research ranges from the biophysics of DNA to synthetic cells and beyond. Please have a look below at the spectrum of our current projects.
Using single-molecule optical and AFM imaging and force-spectroscopy techniques, we seek to unravel the mechanistic aspects of the structure and dynamics of chromosomes. Our research interests include:
Bacterial biophysics and bottom up biology
Our group studies bacterial cell division and is aiming to constitute a ‘bottom up biology’ in synthetic cells that can autonomously divide. Our main interest lies in cell division, chromatin structure, and spatial control. We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks and this assess the fundamental role of spatial confinement at the molecular and cellular level. Our projects include the following:
Nanopores represent an elegant and versatile tool to measure single molecules. We research novel detection modes with solid-state nanopores as well as various ways to measure proteins with nanopores. Projects encompass the following:
Diagnostics for neglected diseases
We develop point-of-care diagnostics test of neglected tropical diseases within resource-limited settings, based on Crspr/Cas9 detecting of pathogen’s DNA in body fluids.